Hemoglobin Levels and Number of Erythrocytes in Scabies-infected Male Mice (Mus musculus) Treated with Water Extract of Taro (Colocasia esculenta (L.) Schott Cultivar Hideung

Hemoglobin Levels and Number of Erythrocytes in Scabies-infected Male Mice (Mus musculus) Treated with Water Extract of Taro (Colocasia esculenta (L.) Schott Cultivar Hideung


  • I Gusti Ayu Manik Widhyastini SCOPUS ID: 57212254933 (Animal Physiology) Department of Biology, Universitas Nusa Bangsa
  • Nia Yuliani
  • Ananda Sarah Nur Azizah




Skabies , Talas, Hemoglobin, Eritrosit, Ivermectin


This study aims to analyze the hemoglobin levels and number of erythrocytes in scabies-infected male mice treated with taro water extract as a cheap and safe alternative treatment for scabies. The test animals were 24 mice weighing 20-25 grams, divided into 6 groups consisting of: K1: taro water extract 100gr/100 ml water, K2 taro water extract 200gr/100ml water, K3: using 300gr/100ml taro water extract water, K4: ivermectin positive control, K5: negative control with water alone, and K6 normal control not infected with scabies and not given treatment. The application of taro extract was carried out for five days. Observations were carried out every day, until day 7. Blood samples were taken from mice three times: before being infected with scabies (healthy), when infected with scabies, and after being treated with taro water extract. The data obtained was processed statistically using the SPSS software with the One Way ANOVA test. Sarcoptes scabiei infection affects the appearance of the blood profile of male mice when infected, there is an increase in the number of erythrocytes but does not affect hemoglobin levels. Treatment with water extract of the taro (Colocasia esculenta (L.) Schott) cultivar hideung in different concentrations did not show significant blood results, but it could heal wounds caused by scabies infection.


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Author Biography

I Gusti Ayu Manik Widhyastini, SCOPUS ID: 57212254933 (Animal Physiology) Department of Biology, Universitas Nusa Bangsa


Agungpriyono, S., Prawira, A. Y., Darusman, H. S., Farida, W. R., & Novelina, S. (2020). Anatomi Makroskopis dan Analisis Dinamika Profil Darah pada Proses Penyembuhan Luka pada Kulit Landak Jawa ( Hystrix javanica ). Jurnal Veteriner, 21(36), 1–13.

Akram, M., Riaz, M., Noreen, S., Shariati, M. A., Shaheen, G., Akhter, N., Parveen, F., Akhtar, N., Zafar, S., Owais Ghauri, A., Riaz, Z., Khan, F. S., Kausar, S., & Zainab, R. (2020). Therapeutic potential of medicinal plants for the management of scabies. Dermatologic Therapy, 33(1). https://doi.org/10.1111/dth.13186

Anderson, K. L., & Strowd, L. C. (2017). Epidemiology, Diagnosis, and Treatment of Scabies in a Dermatology Office. The Journal of the American Board of Family Medicine, 30(1), 78–84. https://doi.org/10.3122/jabfm.2017.01.160190

André, G. L. J., & Richert, B. (2019). Management of scabies in 2019. Revue Medicale de Bruxelles, 40(5), 432–438. https://doi.org/10.30637/2019.19-006

Arlian, L. G., Feldmeier, H., & Morgan, M. S. (2015). The Potential for a Blood Test for Scabies. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0004188

Ashok, P. K., & Upadhyaya, K. (2012). . Journal of Pharmacognosy and Phytochemistry, 1(3), 45–50. http://www.phytojournal.com/archives/?year=2012&vol=1&issue=3&part=A&ArticleId=21

Cushnie, T. P. T., Cushnie, B., & Lamb, A. J. (2014). Alkaloids: An overview of their antibacterial, antibiotic-enhancing and antivirulence activities. International Journal of Antimicrobial Agents, 44(5), 377–386. https://doi.org/10.1016/j.ijantimicag.2014.06.001

Duque, A. P. D. N., Pinto, N. D. C. C., Mendes, R. D. F., Da Silva, J. M., Aragão, D. M. D. O., Castañon, M. C. M. N., & Scio, E. (2016). In vivo wound healing activity of gels containing Cecropia pachystachya leaves. Journal of Pharmacy and Pharmacology, 68(1), 128–138. https://doi.org/10.1111/jphp.12496

Hafner, C. (2009). Skabies. In Hautarzt (Vol. 60, Issue 2). https://doi.org/10.1007/s00105-009-1708-2

Hayashi, Ohki, Nakamura, S., Sugiura, T., Hasegawa, S., Tsuka, Y., Takahashi, N., Kikuchi, S., Matsumura, K., Okumiya, T., Baden, M., & Shiojima, I. (2023). Diagnostic accuracy and clinical usefulness of erythrocyte creatine content to predict the improvement of anaemia in patients receiving maintenance haemodialysis. BMC Nephrology, 24(1), 1–9. https://doi.org/10.1186/s12882-022-03055-4

IEzema, K., Adieme, K. U., Malgwi, I. C., Sabo, R. I., Ayuba, J. A., Tion, P. N., Nguety, M. T., Atuna, S. A., Emeribe, S. T., Shallmizhili, F. O., & Anene, J. J. (2018). Determination of Hemobiochemical Profiles of Apparently Healthy Exotic Breed of Dogs in Jos, Plateau State, Nigeria. Nigeria. Open Journal of Vete-Rinary Medicine, 11, 226–245. https://doi.org/10.4236/ojvm.2021.116015

Krishnapriya, T. V., & Suganthi, A. (2017). Biochemical and phytochemical analysis of colocasia esculenta ( L .) Schott tubers. International Journal of Research in Pharmacy and Pharmaceutical Sciences, 2(3), 21–25.

Liu, J. M., Wang, H. W., Chang, F. W., Liu, Y. P., Chiu, F. H., Lin, Y. C., Cheng, K. C., & Hsu, R. J. (2016). The effects of climate factors on scabies. A 14-year population-based study in Taiwan. Parasite, 23, 1–7. https://doi.org/10.1051/parasite/2016065

Lordani, T. V. A., De Lara, C. E., Ferreira, F. B. P., De Souza Terron Monich, M., Da Silva, C. M., Lordani, C. R. F., Bueno, F. G., Teixeira, J. J. V., & Lonardoni, M. V. C. (2018). Therapeutic effects of medicinal plants on cutaneous wound healing in humans: a systematic review. Mediators of Inflammation, 2018. https://doi.org/10.1155/2018/7354250

Lydeamore, M. J., Campbell, P. T., Regan, D. G., Tong, S. Y. C., Andrews, R. M., Steer, A. C., Romani, L., Kaldor, J. M., McVernon, J., & McCaw, J. M. (2019). A biological model of scabies infection dynamics and treatment informs mass drug administration strategies to increase the likelihood of elimination. Mathematical Biosciences, 309. https://doi.org/10.1016/j.mbs.2018.08.007

Micali, G., Lacarrubba, F., Verzì, A. E., Chosidow, O., & Schwartz, R. A. (2016). Scabies: Advances in Noninvasive Diagnosis. PLoS Neglected Tropical Diseases, 10(6), 1–10. https://doi.org/10.1371/journal.pntd.0004691

Moghimipour, E., & Handali, S. (2015). Saponin: Properties, Methods of Evaluation and Applications. Annual Research & Review in Biology, 5(3), 207–220. https://doi.org/10.9734/arrb/2015/11674

Pereira, P. R., Corrêa, A. C. N. T. F., Vericimo, M. A., & Paschoalin, V. M. F. (2018). Tarin, a Potential Immunomodulator and COX-Inhibitor Lectin Found in Taro (Colocasia esculenta). Comprehensive Reviews in Food Science and Food Safety, 17(4), 878–891. https://doi.org/10.1111/1541-4337.12358

Prajapati, R., Kalariya, M., Umbarkar, R., Parmar, S., & Sheth, N. (2011). Colocasia esculenta: A potent indigenous plant. International Journal of Nutrition, Pharmacology, Neurological Diseases, 1(2), 90. https://doi.org/10.4103/2231-0738.84188

Putra, P. A. G. P., Soma, I. G., & Erawan, I. G. M. K. (2021). Laporan Kasus: Skabiosis Akibat Infeksi Tungau Sarcoptes scabiei pada Anjing Kampung. Indonesia Medicus Veterinus, 10(4), 633–643.

Reyad-ul-Ferdous, M. (2017). Biologically Potential for Pharmacologicals and Phytochemicals of Medicinal Plants of Colocasia esculenta: A Comprehensive Review. American Journal of Clinical and Experimental Medicine, 3(5), 7. https://doi.org/10.11648/j.ajcem.s.2015030501.12

Salavastru, C. M., Chosidow, O., Boffa, M. J., Janier, M., & Tiplica, G. S. (2017). European guideline for the management of scabies. Journal of the European Academy of Dermatology and Venereology, 31(8). https://doi.org/10.1111/jdv.14351

Sharun, K., Anjana, S., Sidhique, S. A., & Panikkassery, S. (2019). Treatment of Sarcoptic mange infestation in rabbits with long acting injectable ivermectin. Journal of Parasitic Diseases, 43(4), 733–736. https://doi.org/10.1007/s12639-019-01137-z

Shashank Kumar and Abhay K. Pandey. (2013). Chemistry and Biological Activities of Flavonoids: An Overview No Title. The Scientific World Journal, 2013. https://doi.org/https://doi.org/10.1155/2013/162750

Silva-Santana, G., Bax, J. C., Fernandes, D. C. S., Bacellar, D. T. L., Hooper, C., Dias, A. A. S. O., Silva, C. B., de Souza, A. M., Ramos, S., Santos, R. A., Pinto, T. R., Ramão, M. A., & Mattos-Guaraldi, A. L. (2020). Clinical hematological and biochemical parameters in Swiss, BALB/c, C57BL/6 and B6D2F1 Mus musculus. Animal Models and Experimental Medicine, 3(4), 304–315. https://doi.org/10.1002/ame2.12139

Sudhakar, P., Thenmozhi, V., Srivignesh, S., & Dhanalakshmi, M. (2020). Colocasia esculenta (L.) Schott: Pharmacognostic and pharmacological review. Journal of Pharmacognosy and Phytochemistry, 9(4), 1382–1386. https://doi.org/10.22271/PHYTO.2020.V9.I4S.11937

Sunderkötter, C., Wohlrab, J., & Hamm, H. (2021). Epidemiologie, Diagnostik und Therapie der Skabies. Deutsches Arzteblatt International, 118(41), 695–704. https://doi.org/10.3238/arztebl.m2021.0296

Tabassum, N., & Hamdani, M. (2014). Plants used to treat skin diseases. Pharmacognosy Reviews, 8(15), 52. https://doi.org/10.4103/0973-7847.125531

Thomas, C., Coates, S. J., Engelman, D., Chosidow, O., & Chang, A. Y. (2020). Ectoparasites: Scabies. In Journal of the American Academy of Dermatology, 82(3). https://doi.org/10.1016/j.jaad.2019.05.109

Wei, W., Ren, Y., Shen, N., Song, H., Xu, J., Hua, R., Zhang, H., Angel, C., Gu, X., Kuang, L., Xie, Y., Peng, X., Xie, X., & Yang, G. (2019). Comparative analysis of host resistance to Sarcoptes scabiei var. cuniculi in two different rabbit breeds. Parasites and Vectors, 12(1), 1–13. https://doi.org/10.1186/s13071-019-3764-5

Widhyastini, I. G. A. M., Nurilmala, F., & Misja, (2020). Ethanol Extract (Colocasia esculenta (L.) Schott.) Hideung Cultivar as Anti-scabies through In-Vitro. Icri 2018, 2151–2158. https://doi.org/10.5220/0009940221512158




How to Cite

Widhyastini, I. G. A. M., Nia Yuliani, & Ananda Sarah Nur Azizah. (2024). Hemoglobin Levels and Number of Erythrocytes in Scabies-infected Male Mice (Mus musculus) Treated with Water Extract of Taro (Colocasia esculenta (L.) Schott Cultivar Hideung. JURNAL SAINS NATURAL, 14(1), 44–52. https://doi.org/10.31938/jsn.v14i1.694